Endocrine Abstracts

Introduction: Congenital combined pituitary hormone deficiency (CCPHD) is a rare disorder characterized by an impaired production of two or more hormones of the anterior pituitary gland. It is linked to different genetic mutations and requires an early diagnosis to prevent burdensome developmental consequences. Primary ovarian insufficiency, disparately is the depletion of ovarian function with loss of functional primordial follicles before the age of 40 years due to multiple ...

Introduction: The occurrence of Cushing’s syndrome in individuals with chronic renal failure is notably rare. It represents a challenging diagnosis in the context of pre-existing chronic kidney disease due to commonly associated alterations in the hypothalamic–pituitary–adrenal axis function. Consequently, the interpretation of standard tests used to detect hypercortisolism can be peculiarly difficult and reveal concrete particularities in comparison to patients...

Introduction: Hyperprolactinemia is a condition of elevated prolactin levels in blood which could be physiological, pathological, or idiopathic in origin. Some cases of hyperprolactinemia have been reported in patients with renal failure. We present a case of hyperprolactinemia, thyrotropic and corticotropic insufficiency in a patient with end-stage renal failure.Case presentation: The patient was 27 years old, with a history of hypertension, renal insuf...

Introduction: Metformin is the first-line treatment of type 2 diabetes mellitus. Poor adherence can be lead to poor glycemic control. The aim of our study was to determine the level of metformin adherence and its link with glycemic control in type 2 diabetic patients.Methods: We performed a cross-sectional study including 273 patients with type 2 diabetes taking metformin for at least three years. We assessed metformin adherence using the Girerd question...

Introduction: Hypothyroidism is a common endocrine disease with reduced systemic metabolism and its treatment consists on hormonal supplementation. However, despite concurrent replacement therapy with high doses of L-thyroxin, some patients might be seen with clinical and biochemical evidence of hypothyroidism. We report a case of persistent hypothyroidism on high dose of levothyroxin.Case presentation: It was a 41-year-old female, with a history of recu...

Introduction: Primary hypothyroidism is a common condition. Its treatment is simple and consists of daily levothyroxine intake. Cases with refractory hypothyroidism despite high doses of levothyroxine were reported. Herein, we report the case of a patient with refractory hypothyroidism secondary to gastrointestinal malabsorption that was improved by L-thyroxine liquid oral substitution.Observation: A 49-year-old woman was admitted for refractory hypothyr...

ObjectiveDescribe the clinical, paraclinical, etiological and therapeutic profile of adrenal incidentalomas.Material and methodsRetrospective study, conducted on 100 patients previously hospitalized in the endocrinology department of the university hospital center RABTA, following the fortuitous discovery of an adrenal mass over a period of 10 years.ResultsThe mea...

Gender is a factor in clinical presentation, biological and morphological characteristics in certain types of pituitary adenomas. Concerning acromegaly, this influence is not well known. In our retrospective study of 32 patients, 12 women and 20 men, hospitalized in our department from 2002 to 2019, we have realized a comparative clinical, para-clinical, therapeutic and prognosis. The median age of women is 47 years, the same as that of men. The average duration of disease pro...

IntroductionAcromegaly is a rare chronic disorder caused by GH hypersecretion. It’s associated with an elevated morbidity and mortality rate. Cardiovascular diseases’ complications are the first cause of mortality in patients. In this study we conducted an assessement of cardivascular risk factors in patients with acromegaly.Patients and methodsA retrospective evaluative study of 32 patients followe...